CASE STUDY

A Review and Analysis on Treatment for Burns and Wounds Using WoundKreme

Case #1

45 Year old Male

A 45-year-old male sustained injuries from an explosion while working on a wood fired steam unit used to heat his home in the winter. The patient suffered a 30% total body surface area full thickness burn to the face, chest, arms, and upper abdomen. The man was taken to a hospital where he was evaluated and admitted to the burn unit. Traditional mechanical debridement under narcotics, intravenous fluids and antibiotics were initiated. WoundKreme treatment was initiated three days later. Figure 1 depicts the injuries sustained prior to receiving WoundKreme treatment. The patient reported pain relief within 1.5 hours of the dressing application. Subsequently, vital signs stayed stable and IV fluids and antibiotics were not required. The patient required no further narcotics during the course of treatment. No infections occurred. No skin grafting was required. Figure 2 shows the patient toward the end of therapy. All burns have healed with minimal to no scarring.

Figure 1

Figure 1

Figure 2

Figure 2

Case #2

Psoriasis

Psoriasis is a chronic autoimmune condition that causes the rapid buildup of skin cells. This buildup of cells causes scaling on the skin’s surface, inflammation and redness around the scales is fairly common. Typical psoriatic scales are whitish-silver and develop in thick, red patches and these patches might crack and bleed. Psoriasis has no cure. Treatments aim to reduce inflammation and scales, slow the growth of skin cells, and remove plaques. WoundKreme applied directly to the skin can be helpful for reducing mild to moderate psoriasis.

Before Treatment

Figure 1

Before Treatment
After Treatment

Figure 2

After Treatment

Case #3

50-Year Old

The patient was a 50-year-old male who sustained injuries from an automated machine which amputated a 2cm by 2cm area of the fat pad of his index finger. The patient was originally scheduled for a skin-grafting procedure however upon treatment with Woundkreme, this was no longer necessary. Over the course of four weeks, the tip of the finger completely re-epithelialized. Fig. 4 shows the finger at the end of treatment. The use of antibiotics were not required during the course of treatment.

Week 1

Figure 1

Week 1
Week 2

Figure 2

Week 2
Week 3

Figure 3

Week 3
Week 4

Figure 4

Week 4

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CASE #4

46 Year Old, Male
Venous Ulcer

The patient developed an infected venous ulcer a year ago. Prior to treatment with WoundKreme, the wound was sloughy and red in appearance. Withing a treatment period of 6 weeks, the wound can be seen to be completely healed and healthy tissue can be observed with minimal scarring.

Before Treatment

Figure 1

Before Treatment
After Treatment

Figure 2

After Treatment

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CASE #5

52 Year Old, Female
Diabetic Foot Ulcer (DFU)

The patient developed a Diabetic Foot Ulcer (DFU) a year ago. Upon presentation, the wound was found to be necrotic and infected, underlying bone and tendon were also found to be exposed. Patient was prescribed antibiotics by the hospital along with WoundKreme treatment. Upon beginning treatment with WoundKreme, healthy tissue granulation was observed and the infection no longer persisted. The figures below depict the changes of the wound over a treatment period of two months, and can be seen as fully healed in Figure 2.

Before Treatment

Figure 1

Before Treatment
After Treatment

Figure 2

After Treatment

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CASE #6

48 Year old, Male
Pressure Ulcer

Patient developed a Pressure Ulcer (Bedsore) on the gluteal region as a result of sleep apnea and immobility due to paralysis. Prior to treatment with WoundKreme, the wound contained necrotic tissue with a visible layer of fats. Wound debridement was performed before the start of the treatment. Over the course of 4 months, patient was treated with WoundKreme during clinical wound dressing sessions. A significant increase in healthy tissue granulation can be seen in Figure 2, while in Figure 3 the wound can be seen as fully healed.

Before Treatment

Figure 1

Before Treatment
Mid Treatment

Figure 2

Mid Treatment
Post Treatment

Figure 3

Post Treatment

Case #7

Boy with 2nd & 3rd Degree Burns

The patient was a young boy who was pushed into a hot stove pipe sustaining significant second and third degree burns to his right palm, all five digits, and the palmar wrist. The child was brought to the local emergency department and was stabilized. The burn team initiated daily dressing changes with WoundKreme twice a day. Figure 1 shows the image of injuries sustained by the patient prior to treatment with WoundKreme. Over three weeks of treatment, the palm, digits and wrist re-epithelialized under community based home care. IV fluids, antibiotics, narcotics and skin grafting were not required. Figure 2 shows the patients hand at the conclusion of a 21 day treatment period.

Day 1

Figure 1

Day 1
Day 21

Figure 2

Day 21

Review of Pharmacological Make up of WoundKreme

 

Before the rapid development of pharmaceuticals, ancient traditional remedies extracted from sources of nature served as the cure to many ailments. Today, Wound healing remains as a challenging clinical problem often leading to complications that result in morbidity. As an effort to reduce this burden, the focus of wound care has shifted towards grasping a better understanding of the underlying physiology as well as the development of new therapeutic approaches to manage acute and long term wound care.

The first ingredient in WoundKreme is honey. Honey is a biological wound dressing with multiple bioactivities that has been used for many centuries now. It provides a moist healing environment which aids to rapidly clear infection, reduce inflammation, edema, and exudation in the wound. It also increases the rate of healing by stimulating the angiogenesis process, granulation of tissue, and re-epithelialization. The combined anti-bacterial and anti-inflammatory properties of honey explains why it should be used in wound healing and it was officially approved by the U.S Federal Drug Administration FDA in 2007 as a recommended option for wound treatment. It has been agreed among researchers that the clearance of an infection by use of honey may also further be attributed to the honey’s immunostimulatory properties directly which in turn stimulates growth and repair of tissues, therefore directly aiding in wound healing. In-vitro studies show honey’s ability to stimulate leukocytes which in turn results in the production of cytokines leading to the stimulation and growth of cells.

WoundKreme also contains a proprietary percentage of natural USP grade beeswax. The benefit of beeswax for wound healing lies in its ability to fight infection and act as a barrier to prevent fluid loss during the exudative phase of wound healing while also sealing moisture into the skin without clogging its pores. In addition to this, it is also rich in vitamins with a high content of vitamin A which has been known to aid in wound healing and stimulate the turnover of new skin cells. When treating patients, beeswax is often used together with other natural products to potentiate the best outcome of its healing properties.  For instance, a mixture of olive oil, honey and beeswax has been found to be extremely effective against bacterial growth of S.Aureus and C.Albicans isolated from patients.  Studies found the average time taken for epithelialization to occur was faster in the patients who received treatment with the topical application of the beeswax mixture as opposed to the controlled group which received a standard clinical dressing.

Most interestingly, WoundKreme contains a botanically infused USP grade olive oil. Olive oil has been used for centuries as skin protectant and lubricant. It has been stated “All foods are medicine and all medicines are food,” Benedictine Padre Benito Jerónimo Feijoo (1676-1764) references to the medicinal value olive oil that can be found in the Bible, the Quran and numerous historical documents. “Olive oil provides the purest fat obtainable and in it bacteria cannot live”. Into this oleic extract are infused several herbs that which will be discussed below.

The first botanical ingredient contained in WoundKreme is Artemisia absinthium. Its common name is wormwood and has been used for over 2000 years. The use of wormwood as an analgesic to relieve pain is attributed to the chemical compound known as “Thujone”. The plant also contains antibacterial and antifungal activities whereby the essential oils derived from wormwood was found to inhibit the growth of various bacteria in-vitro with a particularly high inhibitory activity against the Staphylococcus Aureus strain

The next botanically infused oleic extract ingredient is Althaea officinalis. It is also commonly known as marshmallow root and again is an ancient herb that has been used for millennia. The first recorded use was in 200 BC and it was given the Greek name Althea of “to heal”. The family name, Malvaceae comes from the Greek word malake or “soft” referring to the soft mucilaginous character of the plant. The extract contains a slippery slimy proteoglycan that seems to facilitate the removal of the dressing when it is time for a dressing change.

The remainder of the ingredients in WoundKreme are commonly used and well understood. These include the Aloe Vera plant extract which is commonly used in the treatment of burns and wheat germ oil as a nutritional source of vitamin E to aid in skin repair and minimizing scar tissue.The WoundKreme product improves healing and pain relief trough its vast naturally derived ingredients. The product is not petroleum based. The ingredients are organic time tested products that have been used medicinally for hundreds to thousands of years.

With WoundKreme, as the wound heals, the body naturally debrides the devitalized tissue in a physiologic manner. The healing time varies from individual to individual and is likely affected by the patient’s comorbidities and nutritional status. Devitalized tissue separates from the body in a natural fashion as the new epithelium grows. When the dressings are changed every 12 hours a small amount of devitalized tissue is removed with each dressing change leaving only clean and vitalized tissue that will ultimately heal the wound.